5-Chloro-2-thiophenesulfonamide

Names

[ Name ]:
5-Chloro-2-thiophenesulfonamide

[Synonym ]:
MFCD00052584
2-Thiophenesulfonamide, 5-chloro-
2-Chloro-5-sulfamoylthiophene
T5SJ BSZW EG
5-Chloro-2-thiophenesulfonamide
5-chlorothiophene-2-sulfonamide

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
366.3±52.0 °C at 760 mmHg

[ Melting Point ]:
113-117 °C(lit.)

[ Molecular Formula ]:
C₄H₄ClNO₂S₂

[ Molecular Weight ]:
197.663

[ Flash Point ]:
175.3±30.7 °C

[ Exact Mass ]:
196.937195

[ PSA ]:
96.78000

[ LogP ]:
0.94

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.621

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XN0296000

CHEMICAL NAME :: 2-Thiophenesulfonamide, 5-chloro-

CAS REGISTRY NUMBER :: 53595-66-7

BEILSTEIN REFERENCE NO. :: 0130728

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C4-H4-Cl-N-O2-S2

MOLECULAR WEIGHT :: 197.66

WISWESSER LINE NOTATION :: T5SJ BG ESWZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 19,449,1961

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S45-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as gamma-secretase inhibitors.

Bioorg. Med. Chem. Lett. 18(1) , 375-9, (2008)

Bridgehead substituted derivatives of bicyclo[4.2.1]nonanes were synthesized and shown to be potent inhibitors of gamma-secretase. Two related series were synthesized to explore the SARs. More potent ...

Rhodium-catalyzed aerobic N-alkylation of sulfonamides with alcohols. Feng SL, et al.

Chin. Chem. Lett. 22(9) , 1021-1024., (2011)