2-Aminonicotinic acid

Names

[ Name ]:
2-Aminonicotinic acid

[Synonym ]:
2-Aminopyridine-3-carboxylic acid
2-Amino-3-pyridinecarboxylic acid
MFCD00006318
2-Aminonicotinic acid
Nicotinic acid, 2-amino-
T6NJ BZ CVQ
EINECS 226-296-3

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
342.3±27.0 °C at 760 mmHg

[ Melting Point ]:
295-297 °C (dec.)(lit.)

[ Molecular Formula ]:
C₆H₆N₂O₂

[ Molecular Weight ]:
138.124

[ Flash Point ]:
160.8±23.7 °C

[ Exact Mass ]:
138.042923

[ PSA ]:
76.21000

[ LogP ]:
0.64

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.649

[ Storage condition ]:
Refrigerator

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25-S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29333999

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

2-Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step toward new antiexcitotoxic agents.

J. Med. Chem. 56(23) , 9482-95, (2013)

3-Hydroxyanthranilic acid 3,4-dioxygenase (3-HAO) is the enzyme responsible for the production of the neurotoxic tryptophan metabolite quinolinic acid (QUIN). Elevated brain levels of QUIN are observe...

Alkylation activity and molecular properties of two antineoplastic agents that utilise indometacin and a conjugate of aspirin with 2-aminonicotinic acid to transport nitrogen mustard groups.

Drugs R. D. 8(6) , 363-72, (2007)

Nitrogen mustard (N-mustard) compounds are considered important anticancer drugs. Various transporting agents have been utilised to carry N-mustard groups including coumarins, amides, polyaromatic mol...

Molecular structure (monomeric and dimeric structure) and HOMO-LUMO analysis of 2-aminonicotinic acid: a comparison of calculated spectroscopic properties with FT-IR and UV-vis.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 91 , 83-96, (2012)

The experimental (UV-vis and FT-IR) and theoretical study of 2-aminonicotinic acid (C(6)H(6)N(2)O(2)) was presented in this work. The ultraviolet absorption spectrum of title molecule that dissolved i...