Trisodium 6-O-phosphonato-D-gluconate

Names

[ Name ]:
Trisodium 6-O-phosphonato-D-gluconate

[Synonym ]:
D-Gluconic acid, 6-(dihydrogen phosphate), sodium salt (1:3)
Trisodium 6-O-phosphonato-D-gluconate
6-phosphogluconic acid trisodium salt
MFCD00083681
EINECS 258-543-6

Biological Activity

[Description]:

6-Phosphogluconic acid trisodium is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid trisodium is an endogenous metabolite[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[Target]

phosphoglucose isomerase[1]

[In Vitro]

6-Phosphogluconic acid trisodium (0.5-2.0 mM) completely inhibits the activity of PGI with glucose 6-phosphate (0.05- 0.5 mM) as the substrate[1].

[References]

[1]. Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52.

[2]. Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₁₀Na₃O₁₀P

[ Molecular Weight ]:
342.081

[ Exact Mass ]:
341.970459

[ PSA ]:
203.28000

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 50 mg/mL, clear, colorless

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2931900090

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

Articles

A spectrophotometric method for the determination of creatine phosphokinase and myokinase.

Biochem. J. 61 , 116-22, (1955)

Direct oxidation of glucose-6-phosphate by animal tissues.

Nature 166 , 33, (1950)

A new phosphorylated intermediate in glucose oxidation.

J. Biol. Chem. 210 , 617-626, (1954)

Related Compounds

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