5,7,3',4',5'-Pentamethoxyflavone

Names

[ Name ]:
5,7,3',4',5'-Pentamethoxyflavone

[Synonym ]:
5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one

Biological Activity

[Description]:

3',4',5',5,7-Pentamethoxyflavone, a natural flavonoid extracted from Rutaceae plants, sensitizes chemoresistant cancer cells to chemotherapeutic drugs by inhibition of Nrf2 pathway[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Hou X, et al. 3',4',5',5,7-pentamethoxyflavone sensitizes Cisplatin-resistant A549 cells to Cisplatin by inhibition of Nrf2 pathway. Mol Cells. 2015 May;38(5):396-401.

Chemical & Physical Properties

[ Density]:
1.244g/cm3

[ Boiling Point ]:
554.4ºC at 760mmHg

[ Melting Point ]:
198-200ºC

[ Molecular Formula ]:
C₂₀H₂₀O₇

[ Molecular Weight ]:
372.36900

[ Flash Point ]:
243.5ºC

[ Exact Mass ]:
372.12100

[ PSA ]:
76.36000

[ LogP ]:
3.50300

[ Index of Refraction ]:
1.565

[ Storage condition ]:
2-8°C

Safety Information

[ Safety Phrases ]:
S22-S24/25

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%