Esculin

Names

[ CAS No. ]:
531-75-9

[ Name ]:
Esculin

[Synonym ]:
Crataegin
7-Hydroxy-2-oxo-2H-chromen-6-yl β-D-glucopyranoside
EINECS 208-517-5
Enallachrome
vitaminc2
Esculetin 6-β-D-glucoside
POLYDROM
Bicolorin
Esculetin 6-O-glucoside
Polychrom
7-Hydroxy-2-oxo-2H-chromen-6-yl-β-D-glucopyranoside
BICOLOIN
7-Hydroxycoumarin-6-yl β-D-Glucopyranoside Sesquihydrate
Esculin
7-Hydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-2H-chromen-2-one
Polychrome
6-(β-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one
Esculetin 6-b-D-glucoside
2H-1-Benzopyran-2-one, 6-(β-D-glucopyranosyloxy)-7-hydroxy-
7-Hydroxy-2-oxo-2H-chromen-6-yl β-D-glucopyranoside hydrate (1:1)
Aesculin
MFCD00006879
Esculetin-6-O-glucoside
2H-1-Benzopyran-2-one, 6-(β-D-glucopyranosyloxy)-7-hydroxy-, hydrate (1:1)
Escosyl

Biological Activity

[Description]:

Esculin, a fluorescent coumarin glucoside, is an active ingredient of ash bark[1]. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti‑oxidative stress and anti‑inflammatory effects, via the MAPK signaling pathway[2].

[Related Catalog]:

Research Areas >> Cancer

[Target]

p38 MAPK

[References]

[1]. Knox K, et al. The Coumarin Glucoside, Esculin, Reveals Rapid Changes in Phloem-Transport Velocity in Response to Environmental Cues. Plant Physiol. 2018 Oct;178(2):795-807.

[2]. Song Y, et al. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway. Mol Med Rep. 2018 May;17(5):7395-7402.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
697.7±55.0 °C at 760 mmHg

[ Melting Point ]:
203 °C

[ Molecular Formula ]:
C₁₅H₁₆O₉

[ Molecular Weight ]:
340.29

[ Flash Point ]:
262.8±25.0 °C

[ PSA ]:
149.82000

[ LogP ]:
-1.52

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.689

[ Water Solubility ]:
MODERATELY SOLUBLE

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
F,C,Xi

[ Risk Phrases ]:
R11

[ Safety Phrases ]:
S26-S36/37/39-S45-S24/25

[ RIDADR ]:
UN 2924 3/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
DJ3085000

[ HS Code ]:
2942000000

Customs

[ HS Code ]: 2942000000