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Morellic acid

Names

[ CAS No. ]:
5304-71-2

[ Name ]:
Morellic acid

[Synonym ]:
1-benzyl-2'-(4-methoxyphenyl)-9'-methyl-1',10b'-dihydrospiro[piperidine-4,5'-pyrazolo[1,5-c][1,3]benzoxazine]

Biological Activity

[Description]:

Morellic acid is isolated from Garcinia Morella with an antiangiogenic activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[Target]

IC50: antiangiogenic[1]


[In Vitro]

Morellic acid inhibits the migration of HUVEC at a low concentration of 0.5 µM in HUVEC cell migration assay in vitro[1].

[References]

[1]. Li SL, et al. Improved high-performance liquid chromatographic method for simultaneous determination of 12 cytotoxic caged xanthones in gamboges, a potential anticancer resin from Garcinia hanburyi.Biomed Chromatogr. 2008 Jun;22(6):637-44.

[2]. Yang J, et al.In vitro and in vivo antiangiogenic activity of caged polyprenylated xanthones isolated from Garcinia hanburyi Hook. f. Molecules. 2013 Dec 11;18(12):15305-13.

Chemical & Physical Properties

[ Density]:
1.36±0.1 g/cm3(Predicted)

[ Boiling Point ]:
777.6±60.0 °C(Predicted)

[ Melting Point ]:
94 °C

[ Molecular Formula ]:
C33H36O8

[ Molecular Weight ]:
453.57500

[ Exact Mass ]:
453.24200

[ PSA ]:
37.30000

[ LogP ]:
4.85080

Related Compounds