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XIB-4035

Names

[ CAS No. ]:
529507-84-4

[ Name ]:
XIB-4035

[Synonym ]:
AMINOQUINOL, (R)-
AMINOQUINOL, (S)-
N4-{7-Chloro-2-[(E)-2-(2-chlorophenyl)vinyl]-4-quinolinyl}-N1,N1-diethyl-1,4-pentanediamine
N4-[7-Chloro-2-[(1E)-2-(2-chlorophenyl)ethenyl]-4-quinolinyl]-N1,N1-diethyl-1,4-pentanediamine
aminoquinol
MFCD00601670
UNII:CH1Y88E2AY
1,4-Pentanediamine, N4-[7-chloro-2-[(E)-2-(2-chlorophenyl)ethenyl]-4-quinolinyl]-N1,N1-diethyl-
CH1Y88E2AY
N4-{7-Chloro-2-[(E)-2-(2-chlorophenyl)vinyl]quinolin-4-yl}-N1,N1-diethylpentane-1,4-diamine
N-{7-chloro-2-[2-(2-chlorophenyl)vinyl]-4-quinolinyl}-N-[4-(diethylamino)-1-methylbutyl]amine
N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quin olin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-diamine
XIB4035

Biological Activity

[Description]:

A nonpeptidyl small molecule agonist of GDNF family receptor α1 (GFRα-1); concentration-dependently inhibits [(125)I]GDNF binding in Neuro-2A cells with IC50 of 10.4 uM; induces autophosphorylation of Ret protein, promotes neurite outgrowth in Neuro-2A cells, and induces Ret autophosphorylation in the Neuro-2A cells.

[References]

References 1. Hedstrom KL, et al. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2325-30. 2. Tokugawa K, et al. Neurochem Int. 2003 Jan;42(1):81-6. 3. Höke A. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2060-1. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
597.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H31Cl2N3

[ Molecular Weight ]:
456.450

[ Flash Point ]:
314.9±30.1 °C

[ Exact Mass ]:
455.189514

[ LogP ]:
7.69

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.650

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H413

[ Precautionary Statements ]:
P301 + P310 + P330

[ RIDADR ]:
UN 2811 6.1 / PGIII

Related Compounds