<Suppliers Price>

Eudesmin

Names

[ CAS No. ]:
526-06-7

[ Name ]:
Eudesmin

[Synonym ]:
Pinoresinol dimethyl ether
Eudesamin,Eudesmin
(1S,3aR,4S,6aR)-1,4-Bis(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan
1H,3H-Furo[3,4-c]furan, 1,4-bis(3,4-dimethoxyphenyl)tetrahydro-, (1S,3aR,4S,6aR)-
(7S,7’S,8R,8’R)-eudesmin
(1S,3aR,4S,6aR)-1,4-bis(3,4-dimethoxyphenyl)-hexahydrofuro[3,4-c]furan
eudesmin

Biological Activity

[Description]:

Eudesmin ((-)-Eudesmin) impairs adipogenic differentiation via inhibition of S6K1 signaling pathway. Eudesmin possesses diverse therapeutic effects, including anti-tumor, anti-inflammatory, and anti-bacterial activities[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease
Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK)

[Target]

S6K1[1]


[In Vitro]

Treatment of mesenchymal stem cells (MSCs) with Eudesmin (20, 40, and 80μM) disturbs adipogenesis via suppression of S6K1 signaling pathway. Eudesmin treatment inhibits activation and nuclear translocation of S6K1. S6K1-mediated phosphorylation of H2B at serine 36 (H2BS36p) is reduced upon Eudesmin treatment[1].

[References]

[1]. Ki Hong Nam, et al. Eudesmin Impairs Adipogenic Differentiation via Inhibition of S6K1 Signaling Pathway. Biochem Biophys Res Commun. 2018 Nov 10;505(4):1148-1153.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
517.3±50.0 °C at 760 mmHg

[ Melting Point ]:
108.5-109.5℃

[ Molecular Formula ]:
C22H26O6

[ Molecular Weight ]:
386.438

[ Flash Point ]:
209.8±30.0 °C

[ Exact Mass ]:
386.172943

[ PSA ]:
55.38000

[ LogP ]:
3.08

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.547

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ Safety Phrases ]:
36

Precursor & DownStream

Precursor

DownStream

Related Compounds