(R)-DPN

Names

[ Name ]:
(R)-DPN

[Synonym ]:
(2R)-2,3-Bis(4-hydroxyphenyl)propanenitrile
DMAB-anabaseine dihydrochloride
Benzenepropanenitrile, 4-hydroxy-α-(4-hydroxyphenyl)-, (αR)-

Biological Activity

[Description]:

R)-DPN (compound 3) is a selective ERβ ligand with EC50s of 2.9, 0.8 nM for ERα and ERβ, respectively. (R)-DPN shows a very high affinity and potency preference for ERβ over ERα. (R)-DPN shows cytoxicity for HEC-1 and U2OS cells with EC50s of 286, 205 nM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Endocrinology

[Target]

ERα:2.9 nM (EC50)

ERβ:0.8 nM (EC50)

[References]

[1]. Carroll VM, et al. Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor β-selective ligands. J Med Chem. 2012 Jan 12;55(1):528-37.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
449.4±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₃NO₂

[ Molecular Weight ]:
239.269

[ Flash Point ]:
225.6±25.9 °C

[ Exact Mass ]:
239.094635

[ PSA ]:
64.25000

[ LogP ]:
2.06

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.640

Related Compounds

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