Malic Enzyme inhibitor ME1

Malic enzyme inhibitor ME1 (ME1) is a multifunctional protein involved in glycolysis, the citric acid cycle, NADPH production, glutamine metabolism, and lipogenesis[1]. Malic enzyme inhibitor ME1 regulates one of the main pathways that provide nicotinamide adenine dinucleotide phosphate (NADPH), which is essential for cancer cell growth through maintenance of redox balance and biosynthesis processes in the cytoplasm. Malic enzyme inhibitor ME1 disrupts metabolism in cancer cells and inhibits cancer cell growth by inducing senescence or apoptosis [2].

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Metabolic Disease

[1]. Nakashima C, et al. Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma. Cancer Sci. 2018 Jun;109(6):2036-2045.

[2]. Murai S, et al. Inhibition of malic enzyme 1 disrupts cellular metabolism and leads to vulnerability in cancer cells in glucose-restricted conditions. Oncogenesis. 2017 May 8;6(5):e329.