O-Desmethylnaproxen

[ Boiling Point ]:
444.1ºC at 760mmHg

[ Melting Point ]:
182-183ºC

[ Molecular Formula ]:
C₁₃H₁₂O₃

[ Molecular Weight ]:
216.23300

[ Flash Point ]:
236.5ºC

[ Exact Mass ]:
216.07900

[ PSA ]:
57.53000

[ LogP ]:
2.73350

[ Appearance of Characters ]:
white

[ Storage condition ]:
2-8°C

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H317-H400

[ Precautionary Statements ]:
P273-P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn,N

[ Risk Phrases ]:
22-43-50/53

[ Safety Phrases ]:
36/37-60-61

[ RIDADR ]:
UN 3077 9/PG 3

[ WGK Germany ]:
3

[ HS Code ]:
2918199090

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

The pharmacokinetic profile of naproxen suppository in man.

Int. J. Clin. Pharmacol. Ther. Toxicol. 26(4) , 190-3, (1988)

After a rectal dose of 500 mg in a suppository, naproxen is 6-O-demethylated (20%) and glucuronidated (40%), the metabolites are subsequently excreted renally. The elimination half-life is 15.2 +/- 2....

Sulphation of o-desmethylnaproxen and related compounds by human cytosolic sulfotransferases.

Br. J. Clin. Pharmacol. 60(6) , 632-40, (2005)

Naproxen is a nonsteroidal anti-inflammatory drug widely used as an analgesic and anti-inflammatory agent. The conjugated forms of naproxen and O-DMN, its demethylated metabolite, account for 66-92% o...

High-performance liquid chromatographic determination of 6-desmethylnaproxen sulfate in human plasma.

J. Chromatogr. A. 383(2) , 449-55, (1986)

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