OU749

Names

[ CAS No. ]:
519170-13-9

[ Name ]:
OU749

[Synonym ]:
Benzenesulfonamide, N-[5-[(4-methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-
N-[5-(4-Methoxybenzyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide
OU749

Biological Activity

[Description]:

OU749 is a potent γ-glutamyl transpeptidase (GGT) inhibitor with a Ki value of 17.6 µM. OU749 shows cytotoxicity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

Ki: 17.6 µM (GGT)[1]

[References]

[1]. King JB, et al. A novel, species-specific class of uncompetitive inhibitors of gamma-glutamyl transpeptidase. J Biol Chem. 2009 Apr 3;284(14):9059-65.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
565.6±52.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₅N₃O₃S₂

[ Molecular Weight ]:
361.44

[ Flash Point ]:
295.9±30.7 °C

[ Exact Mass ]:
361.055481

[ PSA ]:
117.80000

[ LogP ]:
3.04

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.644

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis.

Sci. Rep. 6 , 30033, (2016)

Although essential amino acids regulate mechanistic target of rapamycin complex 1 (mTORC1) and the integrated stress response (ISR), the role of cysteine is unknown. We found that in hepatoma HepG2 ce...

Related Compounds

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