JNJ-10311795

Names

[ Name ]:
JNJ-10311795

[Synonym ]:
Phosphonic acid,(2-(3-((methyl(1-(2-naphthalenylcarbonyl)-4-piperidinyl)amino)carbonyl)-2-naphthalenyl)-1-(1-naphthalenyl)-2-oxoethyl)
UNII-W3IL23KVI4
Phosphonic acid,P-(2-(3-((methyl(1-(2-naphthalenylcarbonyl)-4-piperidinyl)amino)carbonyl)-2-naphthalenyl)-1-(1-naphthalenyl)-2-oxoethyl)

Biological Activity

[Description]:

JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM), exhibits noteworthy antiinflammatory activity[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[Target]

Ki: 38 nM (cathepsin G), 2.3 nM (chymase)[1].

[References]

[1]. Lawrence de Garavilla, et al. A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo. J Biol Chem. 2005 May 6;280(18):18001-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₀H₃₅N₂O₆P

[ Molecular Weight ]:
670.68900

[ Exact Mass ]:
670.22300

[ PSA ]:
125.03000

[ LogP ]:
7.56260

Related Compounds

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