Purpurin 18 methyl ester

Names

[ Name ]:
Purpurin 18 methyl ester

[Synonym ]:
Methyl 3-[(10Z,14Z,20Z,22S)-12-ethyl-13,18,22,27-tetramethyl-3,5-dioxo-17-vinyl-4-oxa-8,24,25,26-tetraazahexacyclo[19.2.1.16,9.111,14.116,19.02,7]heptacosa-1(23),2(7),6(27),8,10,12,14,16,18,20 -decaen-23-yl]propanoate

Biological Activity

[Description]:

Purpurin 18 methyl ester, a chlorophyll-a derivative, and is a photosensitizer that can be used in photodynamic therapy (PDT). Purpurin 18 methyl ester has photodynamic activity to induce cancer cell death[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Purpurin 18 methyl ester (1-5 μg/mL; 24 h) has no cytotoxicity in dark in HepG-2 cells[1]. Purpurin 18 methyl ester (1-5 μg/mL; 24 h) decreases the viability of HepG-2 cells in a concentration-dependent manner with irradiation for 10 min[1]. Purpurin 18 methyl ester (0-24 h) is released from GO- Purpurin 18 methyl ester (Pu18) composite, with rates of 47%, 22% and 30% in weak acidic condition (pH 5.6), neutral environment (pH 7.4) and weak alkali condition (pH 8.9) for 24 h, respectively[1].

[References]

[1]. Zhang Y, et, al. pH-Sensitive graphene oxide conjugate Purpurin-18 methyl ester photosensitizer nanocomplex in photodynamic therapy. New Journal of Chemistry. 2018 Jun 26; 42(16):13272-13284.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
778.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₄H₃₄N₄O₅

[ Molecular Weight ]:
578.658

[ Flash Point ]:
424.9±32.9 °C

[ Exact Mass ]:
578.252930

[ LogP ]:
3.80

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.677

Related Compounds

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