Dehydroergosterol

Names

[ CAS No. ]:
516-85-8

[ Name ]:
Dehydroergosterol

[Synonym ]:
Dehydroergosterol
ergosta-5,7,9(11),22-tetraen-3ß-ol
(3S,10S,13R,14R,17R)-17-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,12,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-ol
Ergosta-5,7,9(11),22-tetraen-3β-ol

Biological Activity

[Description]:

Dehydroergosterol is a naturally occurring fluorescent analog of cholesterol (ex/em = 324/375 nm) that mimics the properties of cholesterol in cell membranes. [1] It is readily bound by cholesterol-binding proteins and has been used to probe the sterol environment in real time and elucidate intracellular sterol transport in organisms. [1] References: [1]. McIntosh, AL, Atshaves, BP, Huang, H., et al. A Fluorescent Technique to Study Cholesterol Transport Using Dehydroergosterol. Lipids 43(12), 1185-1208 (2008).

[Related Catalog]:

Research Areas >> Others

Chemical & Physical Properties

[ Density]:
1.02g/cm3

[ Boiling Point ]:
520.6ºC at 760 mmHg

[ Melting Point ]:
146°C (lit.)

[ Molecular Formula ]:
C₂₈H₄₂O

[ Molecular Weight ]:
394.63200

[ Flash Point ]:
221ºC

[ Exact Mass ]:
394.32400

[ PSA ]:
20.23000

[ LogP ]:
7.25090

[ Index of Refraction ]:
1.553

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351-H373

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
40

[ Safety Phrases ]:
36/37

[ RIDADR ]:
NONH for all modes of transport

Articles

Lipid droplet changes in proliferating and quiescent 3T3 fibroblasts.

Histochem. Cell Biol. 129(5) , 611-21, (2008)

Lipid droplets (LDs) are fat-storing organelles present in virtually all eukaryotic cells and involved in many aspects of cell biology related to lipid metabolism and cholesterol homeostasis. In this ...

Spatiotemporal analysis of endocytosis and membrane distribution of fluorescent sterols in living cells.

Histochem. Cell Biol. 130(5) , 891-908, (2008)

Distribution and dynamics of cholesterol in the plasma membrane as well as internalization pathways for sterol from the cell surface are of great cell biological interest. Here, UV-sensitive wide fiel...

Quantitative assessment of sterol traffic in living cells by dual labeling with dehydroergosterol and BODIPY-cholesterol.

Chem. Phys. Lipids 164(3) , 221-35, (2011)

Cholesterol with BODIPY at carbon-24 of the side chain (BCh2) has recently been introduced as new cholesterol probe with superior fluorescence properties. We compare BCh2 with the intrinsically fluore...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.