Rubropunctamine

Names

[ CAS No. ]:
514-66-9

[ Name ]:
Rubropunctamine

[Synonym ]:
Rubropunctamine

Biological Activity

[Description]:

Rubropunctamine is a red azaphilone pigment isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctamine has anti-inflammation activities[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Rubropunctamine (0.32-32 nM; 48 h) inhibits Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), with an IC50 of 433 mol ratio/32 pmol TPA[1]. Rubropunctamine (1 h) exhibits moderate scavenging activity (inhibitory ratio (IR)=1.5) against NO generation by (±)-(E)-methyl-2[(E)-hydroxy-imino]-5-nitro-6-methoxy-3-hexemide (NOR 1) in normal human hepato cells[1].

[In Vivo]

Rubropunctamine inhibits TPA-induced inflammation in mice, with an ID50 of 0.32 mg/ear[1].

[References]

[1]. Akihisa T, et, al. Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects. J Agric Food Chem. 2005 Feb 9;53(3):562-5.

[2]. Patakova P. Monascus secondary metabolites: production and biological activity. J Ind Microbiol Biotechnol. 2013 Feb;40(2):169-81.

Chemical & Physical Properties

[ Density]:
1.22g/cm3

[ Boiling Point ]:
647.1ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₃NO₄

[ Molecular Weight ]:
353.41200

[ Flash Point ]:
345.1ºC

[ Exact Mass ]:
353.16300

[ PSA ]:
76.23000

[ LogP ]:
3.06720

[ Index of Refraction ]:
1.59

Related Compounds

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