8-(4-CHLOROPHENYLTHIO)GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

Names

[ Name ]:
8-(4-CHLOROPHENYLTHIO)GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

[Synonym ]:
sodium,9-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-8-(4-chlorophenyl)sulfanyl-3H-purin-6-one
8-pCPT-cGMP
MFCD00674888

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₄ClN₅NaO₇PS

[ Molecular Weight ]:
509.79300

[ Exact Mass ]:
508.99400

[ PSA ]:
212.75000

[ LogP ]:
2.29990

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Contribution of nitric oxide-dependent guanylate cyclase and reactive oxygen species signaling pathways to desensitization of μ-opioid receptors in the rat locus coeruleus.

Neuropharmacology 99 , 422-31, (2015)

Nitric oxide (NO) is involved in desensitization of μ-opioid receptors (MOR). We used extracellular recordings in vitro to unmask the NO-dependent pathways involved in MOR desensitization in the rat l...

Adenosine modulates light responses of rat retinal ganglion cell photoreceptors througha cAMP-mediated pathway.

J. Physiol. 592(Pt 19) , 4201-20, (2014)

Adenosine is an established neuromodulator in the mammalian retina, with A1 adenosine receptors being especially prevalent in the innermost ganglion cell layer. Activation of A1 receptors causes inhib...

Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity.

Am. J. Physiol. Renal Physiol. 306(12) , F1442-50, (2014)

The emerging role of the transient receptor potential cation channel isotype 6 (TRPC6) as a central contributor to various pathological processes affecting podocytes has generated interest in the deve...

Related Compounds

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