KRP-203 hydrochloride

Names

[ Name ]:
KRP-203 hydrochloride

[Synonym ]:
1,3-Propanediol, 2-amino-2-[2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]-, hydrochloride (1:1)
KRP-203 hydrochloride
2-Amino-2-[2-(4-{[3-(benzyloxy)phenyl]sulfanyl}-2-chlorophenyl)ethyl]-1,3-propanediol hydrochloride (1:1)
KRP-203
2-Amino-2-(4-((3-(benzyloxy)phenyl)thio)-2-chlorophenethyl)propane-1,3-diol hydrochloride

Biological Activity

[Description]:

Mocravimod hydrochloride (KRP-203), an immunosuppressant, is a potent and orally active S1PR1 (sphingosine 1-phosphate receptor type 1) agonist[1][2].

[Target]

S1PR1[1]

[In Vivo]

Mocravimod hydrochloride (KRP-203) ameliorates atherosclerosis in LDL-R−/− Mice[1]. Mocravimod hydrochloride (KRP-203) (orally; 0.1 and 1 mg/kg/day; for 100 days) prolongs graft survival and attenuates chronic rejection in mHC-disparate rat heart allografts[2]. Animal Model: Inbred male DA (MHC haplotype: RT1a) rats[2] Dosage: 0.1 and 1 mg/kg Administration: Orally; daily; for 100 days Result: Prolonged graft survival and attenuated chronic rejection in mHC-disparate rat heart allografts.

[References]

[1]. Potì F, et al. KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R^-/- mice. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1505-12.

[2]. Shimizu H, et al. KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronicrejection in rat skin and heart allografts. Circulation. 2005 Jan 18;111(2):222-9. Epub 2005 Jan 10.

Chemical & Physical Properties

[ Boiling Point ]:
657.1ºC at 760 mmHg

[ Melting Point ]:
199-200ºC (DEC.)

[ Molecular Formula ]:
C₂₄H₂₇Cl₂NO₃S

[ Molecular Weight ]:
480.447

[ Flash Point ]:
351.2ºC

[ Exact Mass ]:
479.108856

[ PSA ]:
101.01000

[ LogP ]:
6.18720

Related Compounds

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