(10β)-10,18-Epoxyros-15-ene-7,18-dione

Names

[ CAS No. ]:
508-71-4

[ Name ]:
(10β)-10,18-Epoxyros-15-ene-7,18-dione

[Synonym ]:
9H-4a,1-(Epoxymethano)phenanthrene-9,12-dione, 7-ethenyldodecahydro-1,4b,7-trimethyl-, (1S,4aR,4bR,7R,8aR,10aS)-
9H-4a,1-(Epoxymethano)phenanthrene-9,12-dione, 7-ethenyldodecahydro-1,4b,7-trimethyl-, (1R,4aR,4bR,7R,8aR,10aS)-
(10β)-10,18-Epoxyros-15-ene-7,18-dione

Biological Activity

[Description]:

Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin and cholesterol ester transfer protein[1][2][3].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> CETP

[References]

[1]. Anis I, et al. Enzyme inhibitory constituents from Duranta repens. Chem Pharm Bull (Tokyo). 2002;50(4):515-518

[2]. Anis I, Ahmed S, Malik A, Yasin A, Choudary MI. Enzyme inhibitory constituents from Duranta repens. Chem Pharm Bull (Tokyo). 2002;50(4):515-518.

[3]. Wang Y, Zhang L, Wang F, Li ZH, Dong ZJ, Liu JK. New Diterpenes from Cultures of the Fungus Engleromyces goetzii and Their CETP Inhibitory Activity [published online ahead of print, 2015 Apr 8]. Nat Prod Bioprospect. 2015;5(2):69-75.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
449.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₈O₃

[ Molecular Weight ]:
316.43

[ Flash Point ]:
196.2±28.8 °C

[ Exact Mass ]:
316.203857

[ PSA ]:
43.37000

[ LogP ]:
3.63

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.541

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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