Cenderitide

Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide activates both pGC-A and pGC-B, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research[1][2][3].

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase

Cenderitide has antiproliferative, anti-fibrotic, and anti-hypertrophic properties[1].

In vivo in normal canines, Cenderitide (10, 50, and 100 ng/kg) is a potent cGMP stimulator that has renal enhancing and cardiac unloading effects, with less reduction of blood pressure[1][4].