2-Methoxy-2,4-diphenyl-3(2H)-furanone

Names

[ Name ]:
2-Methoxy-2,4-diphenyl-3(2H)-furanone

[Synonym ]:
2-Methoxy-2,4-diphenylfuran-3(2H)-one
MFCD00036834
3(2H)-Furanone, 2-methoxy-2,4-diphenyl-
2-Mdpf
2-Methoxy-2,4-diphenyl-3(2H)-furanone
MDPF
2,4-Diphenyl-2-methoxy-3(2H)-furanone,MDPF
2-methoxy-2,4-diphenyl-furan-3-one

Biological Activity

[Description]:

2-Methoxy-2,4-diphenylfuran-3-one is a fluorescent compound which can be used to label gelatin as a substrate for detection of the gelatin degrading MMP-2 and MMP-9 by zymography[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[References]

[1]. Peter Jackson. Detection of phosphoproteins. WO2006070180.

[2]. Danqing Min, et al. 2-Methoxy-2,4-diphenyl-3(2H)-furanone-labeled gelatin zymography and reverse zymography: a rapid real-time method for quantification of matrix metalloproteinases-2 and -9 and tissue inhibitors of metalloproteinases. Electrophoresis. 20

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
426.6±45.0 °C at 760 mmHg

[ Melting Point ]:
96ºC

[ Molecular Formula ]:
C₁₇H₁₄O₃

[ Molecular Weight ]:
266.291

[ Flash Point ]:
203.6±15.1 °C

[ Exact Mass ]:
266.094299

[ PSA ]:
35.53000

[ LogP ]:
3.48

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.618

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2932190090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932190090

[ Summary ]:
2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

Proteolytic activity and cytokine up-regulation by non-albicans Candida albicans.

Arch. Microbiol. 197(4) , 533-7, (2015)

Mouth is an important source of infections and oral infections such as Candida infections increase the risk of mortality. Our purpose was to investigate differences in proteolytic activity of non-albi...

Fluorescent labeling of proteins with nile red and 2-methoxy-2,4-diphenyl-3(2H)-furanone: physicochemical basis and application to the rapid staining of sodium dodecyl sulfate polyacrylamide gels and Western blots.

Electrophoresis 22(5) , 874-80, (2001)

The fluorescent hydrophobic dye Nile red allows the rapid, sensitive, and general staining of proteins in sodium dodecyl sulfate (SDS)-polyacrylamide gels. Nile red staining does not preclude further ...

Rapid imaging, using a cooled charge-coupled-device, of fluorescent two-dimensional polyacrylamide gels produced by labelling proteins in the first-dimensional isoelectric focusing gel with the fluorophore 2-methoxy-2,4-diphenyl-3(2H)furanone.

Electrophoresis 9(7) , 330-9, (1988)

A new method for visualising proteins in two-dimensional polyacrylamide gels was developed. Proteins were labelled with the fluorophore 2-methoxy-2,4-diphenyl-3(2H)furanone (MDPF) while present in the...

Related Compounds

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