Neophytadiene

Names

[ CAS No. ]:
504-96-1

[ Name ]:
Neophytadiene

[Synonym ]:
Neophytadien
3-Methylene-7,11,15-trimethylhexadec-1-ene
7,11,15-Trimethyl-3-methylene-1-hexadecene
3-Methylen-7,11,15-trimethyl-hexadecen-(1)
2,6,10-trimethyl-14-ethylene-14-pentadecene
neophytadiene
2-(4,8,12-Trimethyltridecyl)buta-1,3-diene

Biological Activity

[Description]:

Neophytadiene is a diterpene found in Turbinaria ornate, with anti-inflammatory antioxidant and cardioprotective properties[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Neophytadiene has cytotoxic on RAW 264.7 cells with an IC50 of 50 μM[1]. Neophytadiene (50-100 μM; 30 min) successfully inhibits the NO production level and downregulated inducible nitric oxide synthase (iNOS) production in LPS (1 μg/mL)-induced RAW264.7 cells[1]. Neophytadiene (25-100 μM; 22 hours) significantly inhibits the NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in LPS (1 μg/mL)-induced RAW264.7 cells[1].

[In Vivo]

Neophytadiene (50 mg/kg; p.o.) shows dose-dependent reduction in the alanine aminotransferase (ALT) level[1]. Neophytadiene (25-50 mg/kg; p.o.) significantly reduces LPS (10 mg/kg)-increased IL6 and 1L10 levels and in heart tissue[1]. Neophytadiene (25-50 mg/kg; p.o.) significantly reduces LPS (10 mg/kg)-increased PGE2mRNA expression in heart tissue[1]. Neophytadiene significantly inhibits LPS (10 mg/kg)-induced NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in vivo[1]. Animal Model: Adult male Sprague Dawley rats (6-8 weeks)[1] Dosage: 12 mg/kg, 25 mg/kg, 50 mg/kg Administration: Oral administration, daily, for 7 days Result: Decreased haemoglobin (HGB) level, ALT level, and heart tissue TNF-α, IL1β, NF-κB, iNOS, PI3k/AktandMAPK in LPS (10 mg/kg)-treat rats.

[References]

[1]. Meenakshi Bhardwaj, et al. Neophytadiene from Turbinaria ornata Suppresses LPS-Induced Inflammatory Response in RAW 264.7 Macrophages and Sprague Dawley Rats. Inflammation. 2020 Jun;43(3):937-950.

Chemical & Physical Properties

[ Density]:
0.796g/cm3

[ Boiling Point ]:
344.5ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₃₈

[ Molecular Weight ]:
278.51600

[ Flash Point ]:
160.2ºC

[ Exact Mass ]:
278.29700

[ LogP ]:
7.16770

[ Index of Refraction ]:
1.449

[ Storage condition ]:
20°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.