Shishijimicin B

Names

[ Name ]:
Shishijimicin B

Biological Activity

[Description]:

Shishijimicin B is an active compound of the enediyne class. Shishijimicin B shows extremely potent cytotoxicity with IC50 values of 2.0-3.3 nM. Shishijimicin B has antitumor activity and can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 3.1 nM (3Y1 cells); 3.3 nM (Hela cells); 2.0 nM (P388 cells)[1]

[In Vitro]

Shishijimicin B (compound 2) has high cytotoxicity for 3Y1, Hela and P388 cells with IC50 values of 3.1 nM, 3.3 nM and 2.0 nM, respectively[1].

[References]

[1]. Naoya Oku, et al. Shishijimicins A-C, novel enediyne antitumor antibiotics from the ascidian Didemnum proliferum(1). J Am Chem Soc. 2003 Feb 26;125(8):2044-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₅H₅₀N₄O₁₂S₃

[ Molecular Weight ]:
935.09

Related Compounds

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