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Dasolampanel [USAN:INN]

Names

[ CAS No. ]:
503294-13-1

[ Name ]:
Dasolampanel [USAN:INN]

[Synonym ]:
Dasolampanel
3-Isoquinolinecarboxylic acid, 6-[3-chloro-2-(1H-tetrazol-5-yl)phenoxy]decahydro-, (3S,4aS,6S,8aR)-
(3S,4aS,6S,8aR)-6-[3-Chloro-2-(1H-tetrazol-5-yl)phenoxy]decahydro-3-isoquinolinecarboxylic acid
1P85D6BE9K

Biological Activity

[Description]:

Dasolampanel (NGX426) is an orally bioavailable, competitive antagonist of the AMPA-kainate receptors for the treatment of chronic pain conditions including neuropathic pain and migraine. Migraine Discontinued

[References]

References 1. Wallace MS, et al. Pain Med. 2012 Dec;13(12):1601-10. 2. Martinez-Perez JA, et al. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6463-6. View Related Products by Target iGluR Migraine

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
642.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H20ClN5O3

[ Molecular Weight ]:
377.825

[ Flash Point ]:
342.2±34.3 °C

[ Exact Mass ]:
377.125458

[ LogP ]:
1.99

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.605

Related Compounds