CAY10462

Names

[ Name ]:
CAY10462

[Synonym ]:
1-Hexanamine, 6-[4-(1H-imidazol-1-yl)phenoxy]-N,N-dimethyl-, hydrochloride (1:2)
6-[4-(1H-Imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine dihydrochloride

Biological Activity

[Description]:

CAY 10434 dihydrochloride is a potent CYP4A hydroxylase inhibitor. CAY 10434 dihydrochloride improves contractile response to angiotensin II with the maximal contractile response (Emax) 6764 mg[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

[Target]

CYP4A hydroxylase[1]

[In Vitro]

CAY 10434 dihydrochloride (1 µM；30 分钟) 结合咪康唑可增加内皮完整主动脉环中血管紧张素 II 的累积[1]。

[References]

[1]. Jerez S, et al. 17-Octadecynoic acid improves contractile response to angiotensin II by releasing vasocontrictor prostaglandins. Prostaglandins Other Lipid Mediat. 2012 Jan;97(1-2):36-42.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₇Cl₂N₃O

[ Molecular Weight ]:
360.322

[ Exact Mass ]:
359.153107

[ PSA ]:
30.29000

[ LogP ]:
4.97710

Related Compounds

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