2-Bromo-1-(3-methoxyphenyl)ethanone

Names

[ Name ]:
2-Bromo-1-(3-methoxyphenyl)ethanone

[Synonym ]:
2-Bromo-1-(3-methoxyphenyl)ethanone
Ethanone, 2-bromo-1-(3-methoxyphenyl)-
3'-Methoxyphenacyl BroMide
EINECS 225-666-1
2-Bromo-3‘-methoxyacetophenone
3-(Bromoacetyl)Anisole
2-Bromo-3′-methoxyacetophenone
MFCD00000199

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
278.1±15.0 °C at 760 mmHg

[ Melting Point ]:
60-62 °C(lit.)

[ Molecular Formula ]:
C₉H₉BrO₂

[ Molecular Weight ]:
229.071

[ Flash Point ]:
122.0±20.4 °C

[ Exact Mass ]:
227.978592

[ PSA ]:
26.30000

[ LogP ]:
2.37

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.554

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R22;R34

[ Safety Phrases ]:
S26-S27-S28-S36/37/39-S45

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

The influence of genetic polymorphism of Cyp2c19 isoenzyme on the pharmacokinetics of clopidogrel and its metabolites in patients with cardiovascular diseases.

J. Clin. Pharmacol. 54(8) , 874-80, (2014)

An extensive investigation on pharmacokinetics of clopidogrel and its metabolites as well as pharmacodynamics of the drug was performed in patients with cardiovascular disease carrying various alleles...

Identification of alcohol-dependent clopidogrel metabolites using conventional liquid chromatography/triple quadrupole mass spectrometry.

Rapid Commun. Mass Spectrom. 28(11) , 1285-92, (2014)

Clopidogrel (CLO) is a prodrug used to prevent ischemic events in patients undergoing percutaneous coronary intervention or with myocardial infarction. A previous study found ethyl clopidogrel (ECLO) ...

CYP-independent inhibition of platelet aggregation in rabbits by a mixed disulfide conjugate of clopidogrel.

Thromb. Haemost. 112(6) , 1304-11, (2014)

Dual antiplatelet therapy with clopidogrel and aspirin has been the standard of care in the United States for patients with acute coronary syndromes (ACS) and/or undergoing percutaneous coronary inter...