protheobromine

Names

[ CAS No. ]:
50-39-5

[ Name ]:
protheobromine

[Synonym ]:
1-(2-Hydroxy-propyl)-3,7-dimethyl-3,7-dihydro-purin-2,6-dion
Bonicor
Theocor
1-<2-Hydroxy-propyl>-3,7-dimethyl-xanthin
Pro-Cor
Corodil
Cordabromin
Pantobromino
Protheobromin
Vascopil
Cordaleromin
Protheobromine
1-(2-hydroxy-propyl)-3,7-dimethyl-3,7-dihydro-purine-2,6-dione

Biological Activity

[Description]:

Protheobromine is a cardiotonic and bronchodilator

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. D M Aviado, Pharmacology of pentoxifylline, a hemorheologic agent for the treatment of intermittent claudication. Angiology. 1984 Jul;35(7):407-17.

Chemical & Physical Properties

[ Density]:
1.46g/cm3

[ Boiling Point ]:
493.1ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₄N₄O₃

[ Molecular Weight ]:
238.24300

[ Flash Point ]:
252ºC

[ Exact Mass ]:
238.10700

[ PSA ]:
82.05000

[ Index of Refraction ]:
1.664

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XH2387000

CHEMICAL NAME :: Theobromine, 1-(2-hydroxypropyl)-

CAS REGISTRY NUMBER :: 50-39-5

BEILSTEIN REFERENCE NO. :: 0263332

LAST UPDATED :: 199706

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H14-N4-O3

MOLECULAR WEIGHT :: 238.28

WISWESSER LINE NOTATION :: T56 BN DN FNVNVJ B F H1YQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 6,457,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 580 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 6,601,1956

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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