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Ganglioside GD3 disodium salt

Names

[ CAS No. ]:
497932-19-1

[ Name ]:
Ganglioside GD3 disodium salt

Biological Activity

[Description]:

Ganglioside GD3 disodium salt is a melanoma-associated antigen and has been used as a target for the immune therapy of melanomas[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Ganglioside GD3 is highly expressed in melanomas in comparison with melanocytes, is exclusively expressed in the early developmental stage of the fetal brain, and is highly expressed in activated T lymphocytes and in T cell malignant tumor cells suggest that GD3 is involved in tumor phenotypes, such as enhanced proliferation and frequent metastasis[1].

[References]

[1]. Kazunori Hamamura, et al. Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11041-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C70H123N3Na2O29

[ Molecular Weight ]:
1516.71

Related Compounds