DESACETYLCOLCHICINE-d-TARTRATE
Names
[ CAS No. ]:
49720-72-1
[ Name ]:
DESACETYLCOLCHICINE-d-TARTRATE
[Synonym ]:
Colchicine,deacetyl-,L-tartrate
NCI 1136
TMCA methyl ester d-tartrate,hydrate
SKF 250
Trimethylcolchicinic acid,methyl ether,L-tartrate
Desacetylcolchicine d-tartrate
Chemical & Physical Properties
[ Molecular Formula ]:
C24H29NO11
[ Molecular Weight ]:
507.48700
[ Exact Mass ]:
507.17400
[ PSA ]:
195.07000
[ LogP ]:
1.27190
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GH0980000
- CHEMICAL NAME :
- Colchicinic acid, trimethyl-methyl ether, d-tartrate, hydrate
- CAS REGISTRY NUMBER :
- 49720-72-1
- LAST UPDATED :
- 199610
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C20-H23-N-O5.C4-H6-O6.H2-O
- MOLECULAR WEIGHT :
- 525.56
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 200 ug/kg/7D-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Blood - leukopenia Blood - thrombocytopenia
- REFERENCE :
- CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 56,263,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 70520 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 9500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973