Plathymenin

Names

[ CAS No. ]:
492-12-6

[ Name ]:
Plathymenin

[Synonym ]:
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-6,7-dihydroxy-, (2S)-
(2S)-2-(3,4-Dihydroxyphenyl)-6,7-dihydroxy-2,3-dihydro-4H-chromen-4-one

Biological Activity

[Description]:

Plathymenin is a flavonoid that can be isolated from Nepalese propolis. Plathymenin is a potent inhibitor of 5-LOX[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[References]

[1]. Funakoshi-Tago M, et al. Anti-inflammatory activity of flavonoids in Nepalese propolis is attributed to inhibition of the IL-33 signaling pathway. Int Immunopharmacol. 2015 Mar;25(1):189-98.

[2]. Jiang S, et al. Combined Autodock and comparative molecular field analysis study on predicting 5-lipoxygenase inhibitory activity of flavonoids isolated from Spatholobus suberectus Dunn. Z Naturforsch C J Biosci. 2015;70(3-4):103-13.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
658.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₂O₆

[ Molecular Weight ]:
288.25

[ Flash Point ]:
254.5±25.0 °C

[ Exact Mass ]:
288.063385

[ LogP ]:
1.93

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.725

[ Storage condition ]:
2-8℃