Bufotenine
Names
[ CAS No. ]:
487-93-4
[ Name ]:
Bufotenine
[Synonym ]:
Bufotenin
Cohoba
Mapine
Mappine
Mappin
Bufotenine
N,N-Dimethylserotonin
EINECS 207-667-9
3-[2-(dimethylamino)ethyl]-1H-indol-5-ol
Dimethylserotonin
5-hydroxy-N,N-dimethyltryptamine
N,N-Dimethyl-5-hydroxytryptamine
Chemical & Physical Properties
[ Density]:
1.178g/cm3
[ Boiling Point ]:
392.8ºC at 760 mmHg
[ Melting Point ]:
62-64ºC
[ Molecular Formula ]:
C12H16N2O
[ Molecular Weight ]:
204.26800
[ Flash Point ]:
191.3ºC
[ Exact Mass ]:
204.12600
[ PSA ]:
39.26000
[ LogP ]:
1.97760
[ Vapour Pressure ]:
9.89E-07mmHg at 25°C
[ Index of Refraction ]:
1.646
[ Storage condition ]:
Refrigerator, Under Inert Atmosphere
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NM2800000
- CHEMICAL NAME :
- Indol-5-ol, 3-(2-(dimethylamino)ethyl)-
- CAS REGISTRY NUMBER :
- 487-93-4
- BEILSTEIN REFERENCE NO. :
- 0160628
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C12-H16-N2-O
- MOLECULAR WEIGHT :
- 204.30
- WISWESSER LINE NOTATION :
- T56 BMJ D2N1&1 GQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 57 ug/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - sensory change involving peripheral nerve Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes
- REFERENCE :
- SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 123,886,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 290 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL. Volume(issue)/page/year: 16,385,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64,144,1968
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 2500 mg/kg
- TOXIC EFFECTS :
- Cardiac - other changes
- REFERENCE :
- AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 86,138,1920
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H302 + H312 + H332-H319
[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338
[ Hazard Codes ]:
F,Xn
[ Risk Phrases ]:
11-20/21/22-36
[ Safety Phrases ]:
16-36/37
[ RIDADR ]:
UN 1544
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2933990090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Curr. Drug Metab. 11(8) , 659-66, (2010)
5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) belongs to a group of naturally-occurring psychoactive indolealkylamine drugs. It acts as a nonselective serotonin (5-HT) agonist and causes many physiolog...
Isolation of N,N-dimethyl and N-methylserotonin 5-O-β-glucosides from immature Zanthoxylum piperitum seeds.Biosci. Biotechnol. Biochem. 74(9) , 1951-2, (2010)
Two serotonin derivatives, N,N-dimethylserotonin 5-O-β-glucoside (1a) and N-methylserotonin 5-O-β-glucoside (1b) were isolated from immature seeds of Zanthoxylum piperitum. Their structures were deter...
A critical review of reports of endogenous psychedelic N, N-dimethyltryptamines in humans: 1955-2010.Drug Test. Anal. 4(7-8) , 617-35, (2012)
Three indole alkaloids that possess differing degrees of psychotropic/psychedelic activity have been reported as endogenous substances in humans; N,N-dimethyltryptamine (DMT), 5-hydroxy-DMT (bufotenin...