7-Hydroxy-4'-methoxyflavone

Names

[ CAS No. ]:
487-24-1

[ Name ]:
7-Hydroxy-4'-methoxyflavone

[Synonym ]:
Flavone,7-hydroxy-4'-methoxy
7-Hydroxy-4'-methoxyflavone
EINECS 207-653-2
4'-Methoxy-7-hydroxyflavone

Biological Activity

[Description]:

Pratol is a potent inhibitor of NF-κB. Pratol significantly reduces NO and prostaglandin PGE2 production without any cytotoxic in LPS-stimulated RAW 264.7 cells. Pratol reduces proinflammatory cytokines. Pratol can be used in study inflammatory diseases and cancer[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. Chung, Y. C. , et al. Anti-inflammatory Effect of Pratol in LPS-stimulated RAW 264.7 Cells via NF-κB Signaling Pathways. Natural Product Communications, 13(5), 1934578X1801300.

Chemical & Physical Properties

[ Density]:
1.329g/cm3

[ Boiling Point ]:
479.4ºC at 760mmHg

[ Melting Point ]:
263-264ºC

[ Molecular Formula ]:
C₁₆H₁₂O₄

[ Molecular Weight ]:
268.26

[ Flash Point ]:
183.4ºC

[ Exact Mass ]:
266.09400

[ PSA ]:
39.44000

[ LogP ]:
3.77700

[ Vapour Pressure ]:
8.17E-10mmHg at 25°C

[ Index of Refraction ]:
1.641

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3100110

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 7-hydroxy-2-(4-methoxyphenyl)-

CAS REGISTRY NUMBER :: 487-24-1

BEILSTEIN REFERENCE NO. :: 0237239

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H12-O4

MOLECULAR WEIGHT :: 268.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 38,67,1983

Safety Information

[ Hazard Codes ]:
Xi