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Hydrocinchonine

Names

[ CAS No. ]:
485-65-4

[ Name ]:
Hydrocinchonine

[Synonym ]:
MFCD00216716
(1S)-((2R,4S,5R)-5-Ethylquinuclidin-2-yl)(quinolin-4-yl)methanol
EINECS 207-621-8
10,11-dihydro-cinchonan-9-ol
Cinconifine

Biological Activity

[Description]:

Hydrocinchonine (Dihydrocinchonine) is a multidrug resistance (MDR)-reversal agent. Hydrocinchonine exerts synergistic apoptotic effect with Paclitaxel in MES-SA/DX5 cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Sang-Yun Lee, et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011 Aug;26(4):424-31.  

Chemical & Physical Properties

[ Density]:
1.18 g/cm3

[ Boiling Point ]:
467.1ºC at 760 mmHg

[ Melting Point ]:
269 - 272ºC

[ Molecular Formula ]:
C19H24N2O

[ Molecular Weight ]:
296.40700

[ Flash Point ]:
236.3ºC

[ Exact Mass ]:
296.18900

[ PSA ]:
36.36000

[ LogP ]:
3.32650

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.639

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Precursor & DownStream

Precursor

DownStream