A2ti-2

Names

[ Name ]:
A2ti-2

Biological Activity

[Description]:

A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM[1]. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection[2].

[Related Catalog]:

Research Areas >> Infection

[Target]

IC50: 230 μM (A2t)[1]

[In Vitro]

A2ti-2 (compound 7a) is an annexin A2-S100A10 protein-protein interaction blocker[1]. A2ti-2 is less effective with <50% reduction in HPV16 PsV infection achieved at 100 μM. A2ti-1 decreases HPV16 entry with a 20% reduction at 100 μM[2].

[References]

[1]. Tummala R K Reddy, et al.Three-dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction. ChemMedChem. 2012 Aug;7(8):1435-46.

[2]. Andrew W Woodham, et al. Small Molecule Inhibitors of the Annexin A2 Heterotetramer Prevent Human Papillomavirus Type 16 Infection. J Antimicrob Chemother. 2015;70(6):1686-90.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₈N₄O₂S

[ Molecular Weight ]:
354.43

Related Compounds

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