ANY1

Names

[ Name ]:
ANY1

[Synonym ]:
Pyrazolo[1,5-a]pyrimidin-2(1H)-one, 6,6'-(4-nitro-1H-pyrazole-3,5-diyl)bis[3-bromo-
6,6'-(4-Nitro-1H-pyrazole-3,5-diyl)bis(3-bromopyrazolo[1,5-a]pyrimidin-2(1H)-one)

Biological Activity

[Description]:

ANY1 (FosA inhibitor ANY1) is a small molecule active site inhibitor of FosA (metal-dependent glutathione S-transferase) with IC50 of 5.1 uM (K. pneumoniae FosA); binds to wild-type and mutant FosA3 measured by fluorescence quenching with Kd vales of 440-4880 nM; potentiates Fosfomycin (FOM) activity in representative Gram-negative pathogens.

[References]

References 1. Tomich AD, et al. Antimicrob Agents Chemother. 2019 Jan 14. pii: AAC.01524-18. View Related Products by Target Bacterial

Chemical & Physical Properties

[ Density]:
2.6±0.1 g/cm3

[ Molecular Formula ]:
C₁₅H₇Br₂N₉O₄

[ Molecular Weight ]:
537.082

[ Exact Mass ]:
534.898743

[ LogP ]:
0.00

[ Index of Refraction ]:
2.068

Related Compounds

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