3",8"-Binaringenin

Names

[ Name ]:
3",8"-Binaringenin

[Synonym ]:
8-[5-(5,7-Dihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
3",8"-Binaringenin
4H-1-Benzopyran-4-one, 8-[5-(3,4-dihydro-5,7-dihydroxy-4-oxo-2H-1-benzopyran-2-yl)-2-hydroxyphenyl]-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-

Biological Activity

[Description]:

Tetrahydroamentoflavone (Amentoflavanone) is a potent xanthine oxidase (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC50 and Ki values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout[1].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase

[Target]

IC50: 92 nM (XO)[1]. Ki: 0.982 μM (XO)[1].

[In Vitro]

Tetrahydroamentoflavone 对 XO 具有抑制活性，IC50 和 Ki 值分别为 92 nM 和 0.982 μM[1]。

[References]

[1]. Ranjith Arimboor, et al. Tetrahydroamentoflavone (THA) from Semecarpus anacardium as a potent inhibitor of xanthine oxidase. J Ethnopharmacol. 2011 Feb 16;133(3):1117-20.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
932.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₂₂O₁₀

[ Molecular Weight ]:
542.490

[ Flash Point ]:
314.3±27.8 °C

[ Exact Mass ]:
542.121277

[ PSA ]:
173.98000

[ LogP ]:
5.03

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.745

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds

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