m-PEG3-succinimidyl carbonate

Names

[ Name ]:
m-PEG3-succinimidyl carbonate

[Synonym ]:
8-methoxy-3,6-dioxaoctyl N-succinimidyl carbonate
carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester 2-[2-(2-methoxy-ethoxy)-ethoxy]-ethyl ester
activated triethylene glycol monomethyl oligomer

Biological Activity

[Description]:

m-PEG3-succinimidyl carbonate is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Miller MA, et al. Amphiphilic conjugates of human brain natriuretic peptide designed for oral delivery: in vitro activity screening. Bioconjug Chem. 2006 Mar-Apr;17(2):267-74.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₉NO₈

[ Molecular Weight ]:
305.28100

[ Exact Mass ]:
305.11100

[ PSA ]:
100.60000

[ Storage condition ]:
2-8°C

m-PEG3-succinimidyl carbonate

Names

Biological Activity

Chemical & Physical Properties

Related Compounds