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Eupaglehnin C

Names

[ CAS No. ]:
476630-49-6

[ Name ]:
Eupaglehnin C

[Synonym ]:
2-Butenoic acid, 2-(hydroxymethyl)-, (3aR,4R,6Z,11aR)-2,3,3a,4,5,8,9,11a-octahydro-6,10-dimethyl-3-methylene-2-oxocyclodeca[b]furan-4-yl ester, (2Z)-
(3aR,4R,6Z,11aR)-6,10-Dimethyl-3-methylene-2-oxo-2,3,3a,4,5,8,9,11a-octahydrocyclodeca[b]furan-4-yl (2Z)-2-(hydroxymethyl)-2-butenoate

Biological Activity

[Description]:

Eupaglehnin C is a germacrane-type sesquiterpenoi. Eupaglehnin C can be isolated from the MeOH extract of Eupatorium glehni (Compositae). Eupaglehnin C has cytotoxic activity against HeLa-S3 cancer cell lines[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Eupaglehnin C 抑制 HeLa-S3 的 IC50 为 2.19 mg/mL[2]。

[References]

[1]. Tori M, et al. Seven germacranolides, eupaglehnins A, B, C, D, E, and F, and 2alpha-acetoxyepitulipinolide from Eupatorium glehni. Chem Pharm Bull (Tokyo). 2002 Sep;50(9):1250-4.  

[2]. Zhang ML, et al. Chemical constituents of plants from the genus Eupatorium. Chem Biodivers. 2008 Jan;5(1):40-55.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
528.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H26O5

[ Molecular Weight ]:
346.417

[ Flash Point ]:
184.3±23.6 °C

[ Exact Mass ]:
346.178009

[ LogP ]:
4.26

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.542

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds