Guanfu base H

Names

[ Name ]:
Guanfu base H

Biological Activity

[Description]:

Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC50 values of 4 μM and 3.6 μM, respectively[1][2].

[Related Catalog]:

Research Areas >> Infection

[Target]

Plasmodium falciparum[2]

[References]

[1]. WU Qiong, et al. Simultaneous Determination of Guanfu Base A,Guanfu Base I and Guanfu Base H in Radix Aconitum coreanum(Lévl) Rapaics by RP-HPLC. Progress in Pharmaceutical Sciences. 2011, 35(5), 230-233.

[2]. Wangchuk P, et al. Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum. J Ethnopharmacol. 2010 Aug 9;130(3):559-62.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₃₄ClNO₂

[ Molecular Weight ]:
379.96400

[ Exact Mass ]:
379.22800

[ PSA ]:
43.47000

Related Compounds

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