MCL 0020

Names

[ Name ]:
MCL 0020

Biological Activity

[Description]:

MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor

[Target]

IC50: 11.63 (MC4)

[In Vitro]

MCL0020 inhibited [125I][N1e4, D-Phe7]α-MSH binding to membranes of COS-1 cells with IC50 values of 11.63[1].

[In Vivo]

MCL0020 attenuates swim stress-induced anxiogeniclike behavior in light/dark exploration tests in mice[1]. MCL0020 significantly reverses stress-induced anorexia in rats[1].

[References]

[1]. Chaki S, et al. Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur J Pharmacol. 2003;474(1):95-101.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₄H₃₉N₇O₄

[ Molecular Weight ]:
609.71800

[ Exact Mass ]:
609.30600

[ PSA ]:
192.29000

[ LogP ]:
5.06500

Related Compounds

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