Aristolochic acid B

Names

[ CAS No. ]:
475-80-9

[ Name ]:
Aristolochic acid B

[Synonym ]:
6-Nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid
6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid
Aristolochic Acid B
Phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid, 6-nitro-
Aristolochic acid II

Biological Activity

[Description]:

Aristolochic acid B is one of the major components of Aristolochic acids (AA) which are natural products derived from taxa in the Aristolochiaceae. Aristolochic acid is known to be a potent mutagen and carcinogen. Aristolochic acid B showes more carcinogenic risk than Aristolochic acid A in vivo[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Xing G, et al. Comparison of the mutagenicity of aristolochic acid I and aristolochic acid II in the gpt delta transgenic mouse kidney. Mutat Res. 2012 Mar 18;743(1-2):52-8.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
592.2±50.0 °C at 760 mmHg

[ Melting Point ]:
270-272℃

[ Molecular Formula ]:
C₁₆H₉NO₆

[ Molecular Weight ]:
311.246

[ Flash Point ]:
311.9±30.1 °C

[ Exact Mass ]:
311.042999

[ PSA ]:
101.58000

[ LogP ]:
3.50

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.787

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SF8281600

CHEMICAL NAME :: Phenanthro(3,4-d)-1,3-dioxole-5-carboxylic acid, 6-nitro-

CAS REGISTRY NUMBER :: 475-80-9

BEILSTEIN REFERENCE NO. :: 0329754

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H9-N-O6

MOLECULAR WEIGHT :: 311.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: DNA adduct

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 128 ug/kg

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10,275,1987

Safety Information

[ RIDADR ]:
UN 2811

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Precursor & DownStream

Precursor

DownStream

Related Compounds

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