Odorigenin

Names

[ CAS No. ]:
466-09-1

[ Name ]:
Odorigenin

[Synonym ]:
Odorigenin
5α-Card-20(22)-enolide, 3β,14-dihydroxy-
3b,14-Dihydroxy-5a-card-20(22)-enolide
UZARIGENIN
ODORIGENIN B
Card-20(22)-enolide, 3,14-dihydroxy-, (3β,5α)-
(3β,5α)-3,14-Dihydroxycard-20(22)-enolide
uzarigenine

Biological Activity

[Description]:

Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC50 values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Hosseini SH, et al. Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa. J Nat Prod. 2019 Jan 25;82(1):74-79.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
549.3±50.0 °C at 760 mmHg

[ Melting Point ]:
240-256°

[ Molecular Formula ]:
C₂₃H₃₄O₄

[ Molecular Weight ]:
374.514

[ Flash Point ]:
188.2±23.6 °C

[ Exact Mass ]:
374.245697

[ PSA ]:
66.76000

[ LogP ]:
2.79

[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C

[ Index of Refraction ]:
1.591

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YV1950000

CHEMICAL NAME :: Uzarigenin

CAS REGISTRY NUMBER :: 466-09-1

BEILSTEIN REFERENCE NO. :: 0095446

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C23-H34-O4

MOLECULAR WEIGHT :: 374.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1379 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,1029,1970 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,194,1963

Safety Information

[ Hazard Codes ]:
Xi