Boc-NH-PEG3-CH2COOH

Names

[ Name ]:
Boc-NH-PEG3-CH2COOH

[Synonym ]:
Boc-NH-PEG3-COOH
{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethoxy}-acetic acid
2-[2-{2-(N-tert-butoxycarbonyl)aminoethoxy}ethoxy]ethoxyacetic acid
2,2-dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azohexadecan-16-oic acid
11-N-t-Boc-amino-3,6,9-trioxaundecanoic acid
Boc-NH-mini-PEG-COOH
5,8,11-Trioxa-2-azatridecanedioic acid 1-(1,1-dimethylethyl) ester

Biological Activity

[Description]:

Boc-NH-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Vollmer S, et al. Design, Synthesis, and Biological Evaluation of MEK PROTACs. J Med Chem. 2020 Jan 9;63(1):157-162.

Chemical & Physical Properties

[ Density]:
1.141±0.06 g/cm3

[ Boiling Point ]:
460.1±35.0°C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₂₅NO₇

[ Molecular Weight ]:
307.34000

[ Exact Mass ]:
307.16300

[ PSA ]:
103.32000

[ LogP ]:
1.03640

[ Water Solubility ]:
Soluble (68 g/L) (25 ºC)

Related Compounds

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