3,3'-diiodo-L-thyronine

Names

[ Name ]:
3,3'-diiodo-L-thyronine

[Synonym ]:
3,3’-Diiodo-L-thyronine
O-(4-Hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
3,3'-Diiodo-L-thyronine
L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3-iodo-
EINECS 225-005-7

Biological Activity

[Description]:

3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> COX

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

COX

[In Vitro]

3,3'-Diiodo-L-thyronine (3,3'-T2; 1 μM; 30 min) significantly enhances COX activity[2]. 3,3'-Diiodo-L-thyronine of 1 μM has the maximum effect[2]. 3,3'-Diiodo-L-thyronine is produced by further degradation of T3 and rT3[3].

[References]

[1]. Lorenzini L, et al. Assay of Endogenous 3,5-diiodo-L-thyronine (3,5-T2) and 3,3'-diiodo-L-thyronine (3,3'-T2) in Human Serum: A Feasibility Study. Front Endocrinol (Lausanne). 2019 Feb 19;10:88.

[2]. Lanni A, et al. Rapid stimulation in vitro of rat liver cytochrome oxidase activity by 3,5-diiodo-L-thyronine and by 3,3'-diiodo-L-thyronine. Mol Cell Endocrinol. 1994 Feb;99(1):89-94.

[3]. Chen X, et al. Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomed Chromatogr. 2018 Jun;32(6):e4185.

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
520.7±50.0 °C at 760 mmHg

[ Melting Point ]:
178-180ºC

[ Molecular Formula ]:
C₁₅H₁₃I₂NO₄

[ Molecular Weight ]:
525.077

[ Flash Point ]:
268.7±30.1 °C

[ Exact Mass ]:
524.893372

[ PSA ]:
92.78000

[ LogP ]:
4.55

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.726

[ Storage condition ]:
Amber Vial, -20°C Freezer, Under Inert Atmosphere

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

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Related Compounds

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