Ethyl fluoroacetate
Names
[ CAS No. ]:
459-72-3
[ Name ]:
Ethyl fluoroacetate
[Synonym ]:
Acetic acid, 2-fluoro-, ethyl ester
Ethyl fluoroacetate
EINECS 207-297-8
Ethyl 2-fluoroacetate
MFCD00000450
Fluoroacetic Acid Ethyl Ester
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
118.0±8.0 °C at 760 mmHg
[ Molecular Formula ]:
C4H7FO2
[ Molecular Weight ]:
106.096
[ Flash Point ]:
30.0±0.0 °C
[ Exact Mass ]:
106.043007
[ PSA ]:
26.30000
[ LogP ]:
0.37
[ Vapour Pressure ]:
17.0±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.354
[ Water Solubility ]:
DECOMPOSES
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AH7175000
- CHEMICAL NAME :
- Acetic acid, fluoro-, ethyl ester
- CAS REGISTRY NUMBER :
- 459-72-3
- BEILSTEIN REFERENCE NO. :
- 1743761
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C4-H7-F-O2
- MOLECULAR WEIGHT :
- 106.11
- WISWESSER LINE NOTATION :
- F1VO2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 19 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 11FYAN "Fluorine Chemistry, Volume III. Biological Effects of Organic Fluorides," Simons, J.H., ed., New York, Academic Press, Inc., 1963 Volume(issue)/page/year: 3,59,1963 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 48,225,1951
Safety Information
[ Symbol ]:
GHS02, GHS06, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H226-H300-H400
[ Precautionary Statements ]:
P264-P273-P301 + P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T+:Verytoxic;
[ Risk Phrases ]:
R10;R26/27/28
[ Safety Phrases ]:
S13-S36/37/39-S45-S28A-S16
[ RIDADR ]:
UN 2929 6.1/PG 1
[ WGK Germany ]:
3
[ RTECS ]:
AH7175000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
[ HS Code ]:
29159080
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2915900090
[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%
Articles
J. Med. Chem. 35(17) , 3102-10, (1992)
Four isomers of [(4-fluoro-5-methyl-tetrahydrofuran-2-yl)methyl]trimethylammonium iodide (4-deoxy-4-fluoro-muscarines) were prepared in enantiomerically and diastereomerically pure form from (S)-(-)-m...
A Convenient Synthesis of Ethyl(Diethoxyphosphoryl) fluoroacetate from Ethyl Fluoroacetate. Elkik E and Imbeaux M.Synthesis 1989(11) , 861-62, (1989)
Reactivity of ethyl acetate and its derivatives toward ammonolysis: ramifications for ammonolysis-based microencapsulation process. Chung Y, et al.
Polym. Adv. Technol. 20(10) , 785-94, (2009)