GW6604

Names

[ Name ]:
GW6604

[Synonym ]:
Pyridine, 2-phenyl-4-[5-(2-pyridinyl)-1H-pyrazol-4-yl]-
2-phenyl-4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridine
gw-6604
2-Phenyl-4-[5-(2-pyridinyl)-1H-pyrazol-4-yl]pyridine
unii-273g6sn31h

Biological Activity

[Description]:

GW-6604 is an ALK5 inhibitor with an IC50 value of 140 nM for inhibiting its autophosphorylation, and can be used in the study of liver fibrosis[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

GW-6604(0-10 μM, )抑制 HepG2 细胞中 TGF-β 诱导的 PAI-1 转录和分泌的 IC50 值为 500 nM，有效阻断了 Smad 依赖性反应[1]。

[In Vivo]

GW-6604(p.o., 25-80 mg/kg, twice a day, 3 weeks)在 SD 大鼠急性 DMN 模型中，依赖性地抑制肝脏 COL IA1 过度表达，使其表达降低了 80%。保持了正常的肝脏重量，有效减少了肝纤维化以及增加基质退化[1]。

[References]

[1]. Anne-Charlotte de Gouville, et al. Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis. Br J Pharmacol. 2005 May;145(2):166-77.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
505.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₄N₄

[ Molecular Weight ]:
298.341

[ Flash Point ]:
272.5±16.5 °C

[ Exact Mass ]:
298.121857

[ PSA ]:
54.46000

[ LogP ]:
3.18

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.650

Related Compounds

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