Coenzyme M
Names
[ CAS No. ]:
45127-11-5
[ Name ]:
Coenzyme M
[Synonym ]:
Ethanesulfonic acid, 2,2'-dithiobis-
2,2'-Dithiodiethanesulfonic acid
2,2'-dithiobisethanesulfonic acid
Ethanesulfonic acid,2,2'-dithiobis
2,2'-Disulfanediyldiethanesulfonic acid
Coenzyme
Chemical & Physical Properties
[ Density]:
1.8±0.1 g/cm3
[ Molecular Formula ]:
C4H10O6S4
[ Molecular Weight ]:
282.379
[ Exact Mass ]:
281.936005
[ PSA ]:
176.10000
[ LogP ]:
-1.83
[ Index of Refraction ]:
1.637
Safety Information
[ HS Code ]:
2930909090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2930909090
[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Cancer Chemother. Pharmacol. 67(2) , 381-91, (2011)
Previous studies from our laboratory have identified a role for gamma-glutamyl transpeptidase (GGT) in BNP7787 (disodium 2,2'-dithio-bis ethane sulfonate, dimesna, Tavocept™)-mediated cisplatin nephro...
Phase II randomized study of dose-dense docetaxel and cisplatin every 2 weeks with pegfilgrastim and darbepoetin alfa with and without the chemoprotector BNP7787 in patients with advanced non-small cell lung cancer (CALGB 30303).J. Thorac. Oncol. 3(10) , 1159-65, (2008)
We investigated dose-dense docetaxel and cisplatin in patients with measurable non-small cell lung cancer in a randomized phase II study without [A] or with [B] a putative chemoprotective agent, BNP77...
New approaches to drug discovery and development: a mechanism-based approach to pharmaceutical research and its application to BNP7787, a novel chemoprotective agent.Cancer Chemother. Pharmacol. 52 Suppl 1 , S3-15, (2003)
Any approach applied to drug discovery and development by the medical community and pharmaceutical industry has a direct impact on the future availability of improved, novel, and curative therapies fo...