H-Glu-OtBu

Names

[ Name ]:
H-Glu-OtBu

[Synonym ]:
L-Glutamic acid, 1-(1,1-dimethylethyl) ester
L-Glutamic acid α-tert·butyl ester
(4S)-4-Amino-5-[(2-methyl-2-propanyl)oxy]-5-oxopentanoic acid
(4S)-4-Amino-5-tert-butoxy-5-oxopentanoic acid (non-preferred name)
H-Glu-OtBu

Biological Activity

[Description]:

H-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
326.8±32.0 °C at 760 mmHg

[ Melting Point ]:
140ºC

[ Molecular Formula ]:
C₉H₁₇NO₄

[ Molecular Weight ]:
203.236

[ Flash Point ]:
151.5±25.1 °C

[ Exact Mass ]:
203.115753

[ PSA ]:
89.62000

[ LogP ]:
0.77

[ Appearance of Characters ]:
Powder | White

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.476

[ Storage condition ]:
Store at 0°C

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%