VPC 23019

Names

[ Name ]:
VPC 23019

Biological Activity

[Description]:

VPC23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and a agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively)[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> LPL Receptor

Research Areas >> Inflammation/Immunology

[Target]

pKi: 7.86 (S1P1); 5.93 (S1P3). pEC50: 6.58 (S1P1); 7.07 (S1P3)[1]

[References]

[1]. Davis MD, et al. Sphingosine 1-phosphate analogs as receptor antagonists. J Biol Chem. 2005 Mar 18;280(11):9833-41. Epub 2004 Dec 8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₉N₂O₅P

[ Molecular Weight ]:
372.39600

[ Exact Mass ]:
372.18100

[ PSA ]:
135.18000

[ LogP ]:
4.31450

Related Compounds

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