K00546

Names

[ Name ]:
K00546

[Synonym ]:
MFCD09264159
LFR1253W75
CDK1/2 Inhibitor III
1H-1,2,4-Triazole-1-carbothioamide, 5-amino-3-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-
K-00546
5-Amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphenyl)amino]-1H-1,2,4-triazole-1-carbothioamide

Biological Activity

[Description]:

K00546 is a potent inhibitor of the CDC2-like kinase CLK1 and CLK3 with IC50 of 8.9 and 29.2 nM, respectively.

[References]

References 1. Fedorov O, et al. Chem Biol. 2011 Jan 28;18(1):67-76. 2. Prak K, et al. Biochemistry. 2016 Jan 26;55(3):608-17. View Related Products by Target Cdc2-like Kinase (CLK)

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
649.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₃F₂N₇O₂S₂

[ Molecular Weight ]:
425.436

[ Flash Point ]:
346.4±34.3 °C

[ Exact Mass ]:
425.054016

[ LogP ]:
1.27

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.755

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.